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What Does Alzheimer’s Look Like in Your Brain?
Mohir
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7-5-2008 11:55 AM
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brain
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health
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alzheimer
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<div style="margin: 12px 0px; font-family: arial; color: #333333; background: #ffffff; border: solid 4px #e5e5e5; width: 100%; clear: left;"><div class="CM_CTB_Content_Wrap" style="margin: 0px; padding: 0px;background-color: #ffffff;"><div style="border-bottom: solid 1px #dcdcdc; white-space: nowrap; margin-bottom: 8px; background-color: #eeeeee ;background-image: url(http://clipmarks.com/images/source-bg.gif); background-repeat: repeat-x; height: 24px; line-height: 24px; vertical-align: middle; padding-bottom: 4px; color: #666666; font-size: 10px;" ><a href="http://clipmarks.com/clip-to-blog/" title="see clips that are hot right now"><img src="http://content.clipmarks.com/blog_embed/bb0cedce-bff0-4f0c-baed-4edcdcd2b5fa/F0DF20C6-EE11-482E-A2C6-CC9357F888EC/" alt="" width="19" height="19" border="0" style="vertical-align: middle; margin: 0px 4px; display: inline; border: none; float:none;" /></a>clipped from <a title="http://discovermagazine.com/2008/aug/04-what-does-alzheimer.s-look-like-in-your-brain" href="http://discovermagazine.com/2008/aug/04-what-does-alzheimer.s-look-like-in-your-brain" style="font-size: 11px;">discovermagazine.com</a></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://discovermagazine.com/2008/aug/04-what-does-alzheimer.s-look-like-in-your-brain"><P class="articleDescription">A 3-D rendering of a peptide shows a clear marker of the disease. </P></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://discovermagazine.com/2008/aug/04-what-does-alzheimer.s-look-like-in-your-brain"><div align="center"><img src="http://content8.clipmarks.com/blog_cache/discovermagazine.com/img/BB625D3B-6CFD-44B2-A4CB-8C53FBEFAEDD" alt="" /></div></blockquote><div style="height: 2px; font-size: 2px; background: #dcdcdc; border-bottom: solid 1px #f5f5f5; margin: 2px 4px;"></div><blockquote style="text-align: left; padding: 0px 8px; margin: 4px 0px 8px 0px; background: transparent; border: none;" cite="http://discovermagazine.com/2008/aug/04-what-does-alzheimer.s-look-like-in-your-brain">This A-beta peptide fibril has been rendered in 3-D by a <A target="_blank" href="http://nobelprize.org/educational_games/physics/microscopes/tem/index.html" class="external-link">transmission electron microscope</A>, providing the most detailed look yet at the telltale sign of Alzheimer’s disease. While we still do not know just how Alzheimer’s progresses or what role the fibrils play, they are always found in Alzheimer’s-ridden brains and are considered diagnostic markers of the disease. Marked by the red glow, A-beta peptide may give birth to Alzheimer’s disease through <A href="http://discovermagazine.com/2007/jul/can-we-prevent-alzheimer2019s-disease" class="external-link">mechanisms still unknown</A>. “It could be that the fibrils are toxic outside the cells, killing the neurons,” says <A target="_blank" href="http://www.bio.brandeis.edu/faculty/grigorieff.html" class="external-link">Nikolaus Grigorieff</A>, head of the Brandeis team that created the image. Alternatively, he says, small clumps of the peptide itself could be to blame. “With this 3-D image, we can see what path the peptide takes,” he says, helping us understand the properties of the fibril and get closer to curing this disease.</blockquote></div><div style="margin: 0px 6px 6px 4px;"><table style="font-size: 11px;border-spacing: 0px;padding: 0px;" cellpadding="0" cellspacing="0" width="100%"><tr><td style="background:transparent;border-width:0px;padding:0px;"> </td><td align="right" style="background:transparent;border-width:0px;padding:0px;width:107px" width="107"><a href="http://clipmarks.com/share/F0DF20C6-EE11-482E-A2C6-CC9357F888EC/blog/" title="blog or email this clip"><img src="http://content9.clipmarks.com/images/c2b-foot.png" border="0" alt="blog it" width="107" height="17" style="border-width:0px;padding:0px;margin:0px;" /></a></td></tr></table></div></div>
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